Abstract The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and significant entrants in the development of drug delivery systems owing to their myriad advantages. The NLCs are second-generation SLNs having unstructured matrix, have high drug loading, and provide long-term drug stability in comparison to SLNs and other colloidal systems, which show lower drug loading and experience burst release/drug expulsion during storage. This review is aimed to summarize the formulation development and optimization strategies for NLCs as reported in the literature collected from authentic databases. Various types of NLCs, formulation components, methods of preparation, characterization parameters, optimization (statistical designs) strategies, toxicity, regulatory aspects, and their applications in oral, parenteral, ocular, pulmonary, nose-to-brain, tumor targeting, and transdermal drug delivery have been dealt in detail. Patents granted on the NLCs have also been enlisted.

中文翻译：

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纳米结构脂质载体系统：其配方开发方法、质量优化策略以及药物递送中的最新应用的概要

摘要 基于脂质的胶体载体，如纳米结构脂质载体（NLCs）、固体脂质纳米颗粒（SLNs）、纳米胶囊、脂质体和微乳，由于其众多优势，是药物递送系统开发中最新和重要的进入者。NLC 是具有非结构化基质的第二代 SLN，与 SLN 和其他胶体系统相比，具有高载药量，并提供长期药物稳定性，后者显示出较低的载药量并在储存期间经历突释/药物排出。本综述旨在总结从真实数据库收集的文献中报道的 NLC 的配方开发和优化策略。各种类型的 NLC、配方成分、制备方法、表征参数、已详细讨论了优化（统计设计）策略、毒性、监管方面及其在口服、肠胃外、眼部、肺部、鼻对脑、肿瘤靶向和透皮给药中的应用。在 NLC 上授予的专利也已登记。