Deuterium metabolic imaging (DMI) is an emerging clinically-applicable technique for the non-invasive investigation of tissue metabolism. The generally short T₁ values of ²H-labeled metabolites in vivo can compensate for the relatively low sensitivity of detection by allowing rapid signal acquisition in the absence of significant signal saturation. Studies with deuterated substrates, including [6,6'-²H₂]glucose, [²H₃]acetate, [²H₉]choline and [2,3-²H₂]fumarate have demonstrated the considerable potential of DMI for imaging tissue metabolism and cell death in vivo. The technique is evaluated here in comparison with established metabolic imaging techniques, including PET measurements of 2-deoxy-2-[¹⁸F]fluoro-D-glucose (FDG) uptake and ¹³C MR imaging of the metabolism of hyperpolarized ¹³C-labeled substrates.

氘代谢成像（DMI）是一种新兴的临床适用技术，用于组织代谢的非侵入性研究。² H标记的体内代谢物通常较短的T ₁值可以通过在没有显着信号饱和的情况下允许快速信号采集来补偿相对较低的检测灵敏度。对氘化底物（包括[6,6'- ² H ₂ ]葡萄糖、[ ² H ₃ ]乙酸盐、[ ² H ₉ ]胆碱和[2,3- ² H ₂ ]富马酸盐）的研究表明，DMI 在以下方面具有巨大的潜力：体内组织代谢和细胞死亡成像。在此评估该技术与已建立的代谢成像技术的比较，包括 2-脱氧-2-[ ¹⁸ F]氟-D-葡萄糖 (FDG) 摄取的 PET 测量和超极化¹³ C 标记代谢的¹³ C MR 成像基材。