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Is personalized treatment selection a promising avenue in bpd research? A meta-regression estimating treatment effect heterogeneity in RCTs of BPD.
Journal of Consulting and Clinical Psychology ( IF 7.156 ) Pub Date : 2023-02-16 , DOI: 10.1037/ccp0000803
Tim Kaiser 1 , Philipp Herzog 1
Affiliation  

OBJECTIVE Psychotherapy is the first-line treatment for borderline personality disorder (BPD) in evidence-based care. The effects are, on average, medium; however, nonresponse rates point to differential treatment effects. Personalized treatment selection has the potential to improve outcomes, but they depend on the heterogeneity of treatment effects (HTEs), which this article seeks to establish. METHOD Using an extensive database of randomized controlled trials on psychotherapy for BPD, we determined a reliable estimate of this heterogeneity in treatment effects by (a) applying Bayesian variance ratio meta-analysis and (b) estimating the HTE. In total, 45 studies were included in our study. HTE was found for all psychological treatments, although with low degrees of certainty. RESULTS Across all psychological treatment and control group types, the estimate for the intercept was 0.10, indicating a 10% higher variance of endpoint values in the intervention groups after controlling for differences in posttreatment means. CONCLUSIONS The results suggest that, while there might be sufficient heterogeneity in treatment effects, the estimates are uncertain, and future research is needed to gain more accurate boundaries for HTE. Personalizing psychological treatments for BPD by using treatment selection approaches could have positive effects, but the current evidence does not allow for a precise estimate of potential outcome improvement. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译:

个性化治疗选择是 bpd 研究中有前途的途径吗?BPD 随机对照试验中估计治疗效果异质性的元回归。

目的 心理治疗是循证护理中边缘型人格障碍 (BPD) 的一线治疗方法。平均而言,影响是中等的;然而,无反应率表明不同的治疗效果。个性化治疗选择有可能改善结果,但它们取决于治疗效果 (HTE) 的异质性,本文试图确定这一点。方法 使用 BPD 心理治疗随机对照试验的广泛数据库,我们通过 (a) 应用贝叶斯方差比荟萃分析和 (b) 估计 HTE 确定了治疗效果中这种异质性的可靠估计。我们的研究总共纳入了 45 项研究。所有心理治疗都发现了 HTE,尽管确定性较低。结果 在所有心理治疗和对照组类型中,截距的估计值为 0.10,表明在控制治疗后均值差异后,干预组终点值的方差高 10%。结论 结果表明,虽然治疗效果可能存在足够的异质性,但估计值是不确定的,需要未来的研究来获得更准确的 HTE 界限。通过使用治疗选择方法对 BPD 进行个性化心理治疗可能会产生积极影响,但目前的证据不允许对潜在结果改善进行精确估计。(PsycInfo 数据库记录 (c) 2023 APA,保留所有权利)。结论 结果表明,虽然治疗效果可能存在足够的异质性,但估计值是不确定的,需要未来的研究来获得更准确的 HTE 界限。通过使用治疗选择方法对 BPD 进行个性化心理治疗可能会产生积极影响,但目前的证据不允许对潜在结果改善进行精确估计。(PsycInfo 数据库记录 (c) 2023 APA,保留所有权利)。结论 结果表明,虽然治疗效果可能存在足够的异质性,但估计值是不确定的,需要未来的研究来获得更准确的 HTE 界限。通过使用治疗选择方法对 BPD 进行个性化心理治疗可能会产生积极影响,但目前的证据不允许对潜在结果改善进行精确估计。(PsycInfo 数据库记录 (c) 2023 APA,保留所有权利)。但目前的证据不允许对潜在的结果改善进行精确估计。(PsycInfo 数据库记录 (c) 2023 APA,保留所有权利)。但目前的证据不允许对潜在的结果改善进行精确估计。(PsycInfo 数据库记录 (c) 2023 APA,保留所有权利)。
更新日期:2023-02-16
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