Purpose To assess intraocular pressure (IOP)-induced and gaze-induced optic nerve head (ONH) strains in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). Design Clinic-based cross-sectional study. Methods The ONH from one eye of 228 subjects (114 subjects with HTG (pre-treatment IOP≥21 mm Hg) and 114 with NTG (pre-treatment IOP<21 mm Hg)) was imaged with optical coherence tomography (OCT) under the following conditions: (1) OCT primary gaze, (2) 20° adduction from OCT primary gaze, (3) 20° abduction from OCT primary gaze and (4) OCT primary gaze with acute IOP elevation (to approximately 33 mm Hg). We then performed digital volume correlation analysis to quantify IOP-induced and gaze-induced ONH tissue deformations and strains. Results Across all subjects, adduction generated high effective strain (4.4%±2.3%) in the LC tissue with no significant difference (p>0.05) with those induced by IOP elevation (4.5%±2.4%); while abduction generated significantly lower (p=0.01) effective strain (3.1%±1.9%). The lamina cribrosa (LC) of HTG subjects exhibited significantly higher effective strain than those of NTG subjects under IOP elevation (HTG: 4.6%±1.7% vs NTG: 4.1%±1.5%, p<0.05). Conversely, the LC of NTG subjects exhibited significantly higher effective strain than those of HTG subjects under adduction (NTG: 4.9%±1.9% vs HTG: 4.0%±1.4%, p<0.05). Conclusion We found that NTG subjects experienced higher strains due to adduction than HTG subjects, while HTG subjects experienced higher strain due to IOP elevation than NTG subjects—and that these differences were most pronounced in the LC tissue. Data are available upon reasonable request. Deidentified patient data (ONH strains) is available upon request.

中文翻译：

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内收导致正常眼压青光眼受试者视神经乳头发生较大变形

目的 评估高眼压青光眼 (HTG) 和正常眼压青光眼 (NTG) 受试者的眼压 (IOP) 诱发和凝视诱发的视神经乳头 (ONH) 应变。设计基于临床的横断面研究。方法采用光学相干断层扫描（OCT）对 228 名受试者（其中 114 名受试者患有 HTG（治疗前 IOP≥21 mm Hg），114 名受试者患有 NTG（治疗前 IOP<21 mm Hg））一只眼睛的 ONH 进行成像。以下条件：(1) OCT 主要凝视，(2) OCT 主要凝视内收 20°，(3) OCT 主要凝视外展 20°，以及 (4) OCT 主要凝视伴有急性眼压升高（至约 33 mm Hg）。然后，我们进行数字体积相关分析，以量化 IOP 引起和凝视引起的 ONH 组织变形和应变。结果 对于所有受试者，内收在 LC 组织中产生了高效应变（4.4%±2.3%），与 IOP 升高引起的应变（4.5%±2.4%）没有显着差异（p>0.05）；而外展产生的有效应变显着较低（p=0.01）（3.1%±1.9%）。在 IOP 升高的情况下，HTG 受试者的筛板 (LC) 表现出显着高于 NTG 受试者的有效应变（HTG：4.6%±1.7% vs NTG：4.1%±1.5%，p<0.05）。相反，在内收时NTG受试者的LC表现出显着高于HTG受试者的有效应变（NTG：4.9％±1.9％ vs HTG：4.0％±1.4％，p <0.05）。结论 我们发现 NTG 受试者比 HTG 受试者因内收而经历更高的应变，而 HTG 受试者因 IOP 升高而比 NTG 受试者经历更高的应变，并且这些差异在 LC 组织中最为明显。数据可根据合理要求提供。可根据要求提供未识别的患者数据（ONH 菌株）。