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Exploring mental health from the perspective of DNA methylation: evidence from the hospitality employees
Journal of Hospitality Marketing & Management ( IF 12.5 ) Pub Date : 2023-04-08 , DOI: 10.1080/19368623.2023.2199315
Wei Xiong 1, 2, 3 , Meijiao Huang 1 , Bendegul Okumus 4 , Fang Fan 2, 3
Affiliation  

ABSTRACT

Awareness of work-related stress or mental health has been increasing in global tourism, but there has often been a dilemma to deal with it properly. In this paper, we adopted the allostatic load model and differential susceptibility model to conduct an interdisciplinary study. Study 1 collected longitudinal data and adopted a latent class growth analysis to identify two major growth trajectories of mental health: escalating class and normative class. Study 2 showed that significant DNA methylation (>10%) occurred at some loci of the target genes (NR3C1, FKBP5, NGFR, DRD3, and SLC6A4). The DNA methylation level of the escalating class was higher than the normative class in FKBP5, SLC6A4, and NGFR, which could be recognized as susceptibility genes of hotel employees in the stressful working environment. This study illustrated the potential of psychobiology in solving the mental health issues of hotel employees theoretically and practically.



中文翻译:

从DNA甲基化的角度探讨心理健康:来自酒店员工的证据

摘要

全球旅游业对工作压力或心理健康的认识不断增强,但如何妥善应对却常常面临困境。本文采用非稳态负荷模型和微分磁化率模型进行跨学科研究。研究一收集纵向数据,采用潜在阶层成长分析,确定心理健康的两大成长轨迹:升级阶层和规范阶层。研究 2 显示,目标基因的某些位点(NR3C1、FKBP5、NGFR、DRD3 和 SLC6A4)发生了显着的 DNA 甲基化 (>10%)。升级阶层的FKBP5、SLC6A4、NGFR的DNA甲基化水平高于正常阶层,可以认为是酒店员工在压力工作环境下的易感基因。

更新日期:2023-04-08
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