Aim To evaluate the role of papillary vitreous detachment in the pathogenesis of non-arteritic anterior ischaemic optic neuropathy (NAION) by comparing the features of vitreopapillary interface between NAION patients and normal individuals. Methods This study included 22 acute NAION patients (25 eyes), 21 non-acute NAION patients (23 eyes) and 23 normal individuals (34 eyes). All study participants underwent swept-source optical coherence tomography to assess the vitreopapillary interface, peripapillary wrinkles and peripapillary superficial vessel protrusion. The statistical correlations between peripapillary superficial vessel protrusion measurements and NAION were analysed. Two NAION patients underwent standard pars plana vitrectomy. Results Incomplete papillary vitreous detachment was noted in all acute NAION patients. The prevalence of peripapillary wrinkles was 68% (17/25), 30% (7/23) and 0% (0/34), and the prevalence of peripapillary superficial vessel protrusion was 44% (11/25), 91% (21/23) and 0% (0/34) in the acute, non-acute NAION and control groups, respectively. The prevalence of peripapillary superficial vessel protrusion was 88.9% in the eyes without retinal nerve fibre layer thinning. Furthermore, the number of peripapillary superficial vessel protrusions in the superior quadrant was significantly higher than that in the other quadrants in eyes with NAION, consistent with the more damaged visual field defect regions. Peripapillary wrinkles and visual field defects in two patients with NAION were significantly attenuated within 1 week and 1 month after the release of vitreous connections, respectively. Conclusion Peripapillary wrinkles and superficial vessel protrusion may be signs of papillary vitreous detachment-related traction in NAION. Papillary vitreous detachment may play an important role in NAION pathogenesis. No data are available.

中文翻译：

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乳头状玻璃体脱离可能是非动脉炎性前部缺血性视神经病变的共犯

目的 通过比较非动脉炎性前部缺血性视神经病变（NAION）患者与正常人玻璃体乳头界面的特征，探讨乳头状玻璃体脱离在NAION发病机制中的作用。方法本研究包括22例急性NAION患者（25只眼）、21例非急性NAION患者（23只眼）和23名正常人（34只眼）。所有研究参与者均接受了扫源光学相干断层扫描，以评估玻璃体乳头界面、乳头周围皱纹和乳头周围浅表血管突出。分析了乳头周围浅表血管突出测量值与 NAION 之间的统计相关性。两名 NAION 患者接受了标准玻璃体切除术。结果 所有急性 NAION 患者均出现不完全性乳头状玻璃体脱离。乳头周围皱纹的发生率为 68%（17/25）、30%（7/23）和 0%（0/34），乳头周围浅血管突出的发生率为 44%（11/25）、91%（急性、非急性 NAION 和对照组分别为 21/23) 和 0% (0/34)。在没有视网膜神经纤维层变薄的眼中，视乳头周围浅血管突出的发生率为88.9%。此外，NAION眼上象限中视乳头周围浅表血管突出的数量显着高于其他象限，这与受损较多的视野缺损区域一致。两名 NAION 患者的视乳头周围皱纹和视野缺损分别在玻璃体连接松解后 1 周和 1 个月内显着减轻。结论 乳头周围皱纹和浅表血管突出可能是 NAION 乳头状玻璃体脱离相关牵引的征象。乳头状玻璃体脱离可能在 NAION 发病机制中发挥重要作用。无可用数据。