Blinding of randomised controlled trials (RCTs) is very important for the accurate assessment of drug efficacy. Without proper blinding, the effect of the intervention may be overestimated. Fergusson et al investigated the top journals in psychiatry from 1998 to 2001 and reported that blinding assessments were conducted in only 8 of 94 studies across psychiatric disorders.1 However, no studies on antipsychotic drugs were included among these eight. Hróbjartsson et al investigated RCTs published in 2001, and blinding assessments were conducted in 12 psychiatric studies.2 There were only two studies on antipsychotics but these did not focus on schizophrenia. Baethge et al searched for studies on schizophrenia and affective disorders from 2000 to 2010 to assess whether blinding was appropriately performed.3 Only 5 of the 672 schizophrenia studies, including those on pharmacotherapies and physical therapies, reported blinding assessment, and studies on schizophrenia tended to assess blindness less frequently than studies on affective disorders.3 Thus, of the many double-blind RCTs of antipsychotic drugs conducted to date in the field of schizophrenia, it is unclear how many studies in total have assessed the successfulness of their blinding and if they were successful. Therefore, the objectives of this study were to clarify: (1) the proportion of RCTs of antipsychotics for schizophrenia in which blinding was assessed …

中文翻译：

---

精神分裂症急性治疗抗精神病试验的致盲成功：系统评价

随机对照试验（RCT）的盲法对于准确评估药物疗效非常重要。如果没有适当的盲法，干预的效果可能会被高估。Fergusson 等人调查了 1998 年至 2001 年间精神病学领域的顶级期刊，报告称，94 项精神疾病研究中，只有 8 项进行了盲法评估。1 然而，这 8 项研究中没有纳入抗精神病药物的研究。Hróbjartsson 等人调查了 2001 年发表的随机对照试验，并对 12 项精神病学研究进行了盲法评估。2 只有两项关于抗精神病药物的研究，但这些研究并不关注精神分裂症。Baethge 等人检索了 2000 年至 2010 年有关精神分裂症和情感障碍的研究，以评估盲法是否适当进行。 3 在 672 项精神分裂症研究中，只有 5 项（包括药物疗法和物理疗法的研究）报告了盲法评估，而有关精神分裂症的研究倾向于与情感障碍研究相比，评估失明的频率较低。3因此，迄今为止在精神分裂症领域进行的许多抗精神病药物双盲 RCT 中，尚不清楚总共有多少研究评估了其盲法的成功性，以及它们是否有效。成功了。因此，本研究的目的是澄清：（1）抗精神病药物治疗精神分裂症的随机对照试验中进行盲法评估的比例……