A growing number of studies have demonstrated that the skeleton is an endocrine organ that is involved in glucose metabolism and plays a significant role in human glucose homeostasis. However, there is still a limited understanding of the in vivo glucose uptake and distribution across the human skeleton. To address this issue, we aimed to elucidate the detailed profile of glucose uptake across the skeleton using a total-body positron emission tomography (PET) scanner. A total of 41 healthy participants were recruited. Two of them received a 1-hour dynamic total-body ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) PET scan, and all of them received a 10-minute static total-body ¹⁸F-FDG PET scan. The net influx rate (K_i) and standardized uptake value normalized by lean body mass (SUL) were calculated as indicators of glucose uptake from the dynamic and static PET data, respectively. The results showed that the vertebrae, hip bone and skull had relatively high K_i and SUL values compared with metabolic organs such as the liver. Both the K_i and SUL were higher in the epiphyseal, metaphyseal and cortical regions of long bones. Moreover, trends associated with age and overweight with glucose uptake (SUL_max and SUL_mean) in bones were uncovered. Overall, these results indicate that the skeleton is a site with significant glucose uptake, and skeletal glucose uptake can be affected by age and dysregulated metabolism.

越来越多的研究表明，骨骼是参与葡萄糖代谢的内分泌器官，在人体葡萄糖稳态中发挥着重要作用。然而，对体内葡萄糖摄取和人体骨骼分布的了解仍然有限。为了解决这个问题，我们的目标是使用全身正电子发射断层扫描 (PET) 扫描仪阐明整个骨骼中葡萄糖摄取的详细情况。总共招募了 41 名健康参与者。其中两人接受了 1 小时动态全身¹⁸ F-氟脱氧葡萄糖 ( ¹⁸ F-FDG) PET 扫描，所有人都接受了 10 分钟静态全身¹⁸ F-FDG PET 扫描。净流入率 (K _i）和按去脂体重（SUL）归一化的标准化摄取值分别计算为动态和静态 PET 数据中葡萄糖摄取的指标。结果显示，与肝脏等代谢器官相比，椎骨、髋骨和颅骨的K _{i和SUL值相对较高。}长骨骨骺、干骺端和皮质区域的K _i和 SUL 均较高。此外，还发现了年龄和超重与骨骼中葡萄糖摄取（SUL_最大值和 SUL_平均值）相关的趋势。总的来说，这些结果表明骨骼是一个具有显着葡萄糖摄取的部位，骨骼葡萄糖摄取可能受到年龄和代谢失调的影响。