Despite widespread clinical, theoretical, and empirical support for the importance of alliance ruptures, little is known about the underlying biological level at times of rupture. The overarching goal of the present study was to investigate dyadic patterns of in-session oxytocin (OT) change between patients and therapists (e.g., patient's OT increases more than therapist's OT) as markers of withdrawal ruptures. Hypothesis 1 construed that OT incongruence (e.g., larger patient increase in OT in comparison to their therapist OT increase) will mark the occurrence of withdrawal ruptures. Hypothesis 2 construed that this effect of OT incongruence will be more pronounced when anxious attachment orientation is low. Surface analysis was conducted on 628 saliva samples that were gathered before and after therapeutic sessions of 53 patient-therapist dyads enrolled in a randomized control trial treating major depression. Only Hypothesis 2 received empirical support, meaning it was only when anxious attachment orientation was low that there were significantly more withdrawal ruptures when the patient's OT increase was higher than their therapist's OT increase. This is consistent with the literature, suggesting that in times of withdrawal ruptures, the patient and therapist are in an incongruent state. Findings suggest that this incongruence is mirrored at the biological level only when anxious attachment orientation is low. Results shed light on what may be happening between patients and therapists on a biological level during a withdrawal rupture. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

中文翻译：

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戒断破裂的生物标志：催产素释放不一致的二元模式。

尽管临床、理论和经验都支持联盟破裂的重要性，但人们对破裂时潜在的生物学水平知之甚少。本研究的总体目标是调查患者和治疗师之间催产素（OT）变化的二元模式（例如，患者的 OT 增加超过治疗师的 OT）作为戒断破裂的标志。假设 1 认为 OT 不一致（例如，与治疗师 OT 增加相比，患者 OT 增加较大）将标志着撤退性破裂的发生。假设 2 认为，当焦虑依恋取向较低时，OT 不一致的影响会更加明显。对参加一项治疗重度抑郁症的随机对照试验的 53 名患者-治疗师二人组的治疗前后收集的 628 份唾液样本进行了表面分析。只有假设 2 得到了实证支持，这意味着只有当焦虑依恋取向较低时，当患者的 OT 增加高于治疗师的 OT 增加时，才会出现更多的戒断破裂。这与文献一致，表明在戒断破裂时，患者和治疗师处于不一致的状态。研究结果表明，只有当焦虑依恋取向较低时，这种不一致才会在生物学层面上反映出来。结果揭示了戒断破裂期间患者和治疗师之间在生物学层面上可能发生的情况。（PsycInfo 数据库记录 (c) 2023 APA，保留所有权利）。