Burn injuries are a significant cause of death worldwide, leading to systemic inflammation, multiple organ failure and sepsis. The progression of burn injury is explicitly correlated with mitochondrial homeostasis, which is disrupted by the hyperinflammation induced by burn injury, leading to mitochondrial dysfunction and cell death. Mitophagy plays a crucial role in maintaining cellular homeostasis by selectively removing damaged mitochondria. A growing body of evidence from various disease models suggest that pharmacological interventions targeting mitophagy could be a promising therapeutic strategy. Recent studies have shown that mitophagy plays a crucial role in wound healing and burn injury. Furthermore, chemicals targeting mitophagy have also been shown to improve wound recovery, highlighting the potential for novel therapeutic strategies based on an in-depth exploration of the molecular mechanisms regulating mitophagy and its association with skin wound healing.

中文翻译：

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线粒体功能障碍和线粒体自噬：烧伤和伤口愈合的关键因素

烧伤是全世界死亡的重要原因，导致全身炎症、多器官衰竭和败血症。烧伤的进展与线粒体稳态明显相关，烧伤引起的过度炎症会破坏线粒体稳态，导致线粒体功能障碍和细胞死亡。线粒体自噬通过选择性去除受损的线粒体，在维持细胞稳态中发挥着至关重要的作用。来自各种疾病模型的越来越多的证据表明，针对线粒体自噬的药物干预可能是一种有前途的治疗策略。最近的研究表明线粒体自噬在伤口愈合和烧伤中起着至关重要的作用。此外，针对线粒体自噬的化学物质也被证明可以改善伤口恢复，突显了基于对调节线粒体自噬的分子机制及其与皮肤伤口愈合的关系的深入探索的新型治疗策略的潜力。