Clinical guidelines recommend providing physical activity interventions (PAIs) to people with schizophrenia or bipolar disorder for weight management. However, the cost-effectiveness of PAIs is unknown.

To evaluate the availability and methodological quality of economic evaluations of PAIs for people with schizophrenia or bipolar disorder.

Four databases (MEDLINE, Embase, PsycInfo and Scopus) were searched on 5 July 2022. Based on the retrieved studies, forward and backward citation searches were conducted. Two reviewers independently selected studies for inclusion. Study quality was assessed using the Drummond checklist. Review results were presented using narrative synthesis.

Fourteen articles reporting nine studies were included. All included studies assessed PAIs within a multicomponent lifestyle intervention. Mixed findings were reported on the cost-effectiveness of multicomponent lifestyle intervention: three studies reported it as cost-effective; four studies reported it as not cost-effective; and two studies did not conclude whether it was cost-effective or not. Very limited evidence suggests that certain patient subgroups might be more likely to benefit from multicomponent lifestyle interventions with a PAI component: men; individuals with comorbid type 2 diabetes; and individuals who have been psychiatric hospital in-patients for ≥1 year. The quality of included studies ranged from moderate to high.

The current economic evidence suggests that not all modalities of multicomponent lifestyle intervention including a PAI component are cost-effective for people with schizophrenia or bipolar disorder; and not all people with schizophrenia or bipolar disorder would benefit equally from the intervention. Future research is urgently needed to identify the cost-effective modality of PAI for different patient subgroups.

临床指南建议为精神分裂症或双相情感障碍患者提供体力活动干预（PAI）以控制体重。然而，PAI 的成本效益尚不清楚。

评估精神分裂症或双相情感障碍患者 PAI 经济评估的可用性和方法质量。

于 2022 年 7 月 5 日检索了四个数据库（MEDLINE、Embase、PsycInfo 和 Scopus）。根据检索到的研究，进行了前向和后向引文检索。两名评审员独立选择纳入研究。使用 Drummond 检查表评估研究质量。审查结果采用叙述综合的方式呈现。

其中包括报告九项研究的十四篇文章。所有纳入的研究均在多成分生活方式干预中评估了 PAI。关于多成分生活方式干预的成本效益，报告的结果不一：三项研究报告其具有成本效益；四项研究报告称其不具有成本效益；两项研究并未得出其是否具有成本效益的结论。非常有限的证据表明，某些患者亚组可能更有可能受益于包含 PAI 成分的多组分生活方式干预措施：男性；合并 2 型糖尿病的个体；精神科医院住院时间≥1年的患者。纳入研究的质量从中到高不等。

目前的经济证据表明，并非所有多成分生活方式干预（包括 PAI 成分）对于精神分裂症或躁郁症患者来说都是具有成本效益的；并非所有精神分裂症或双相情感障碍患者都能从干预中平等受益。未来的研究迫切需要确定针对不同患者亚组的 PAI 的成本效益模式。