The human body is limited in healing neurological damage caused by diseases or traumatic injuries. Bioelectricity is a quintessential characteristic of neural tissue and has a crucial role in physiological and neurological therapeutics development. Here, a wireless electromagnetic neural stimulation patch was created, combining stimulation through electromagnetic induction with physical guidance cues through structural anisotropy. The melt electrowritten biocompatible, bioresorbable polycaprolactone anisotropic structure with glancing angle deposition of 80 nm gold directly endowed incorporation of a wireless energy harvesting component in the patch, as an electromagnetic stimulation delivery system directly interfacing with neural cells. The biocompatibility and the capacity of the patch to deliver electromagnetic stimulation and promote neurite outgrowth was confirmed in vitro. Electromagnetically (60 mV, 40 kHz, 2 h/day, 5 days) stimulated PC12 cells showed 73.2% increased neurite outgrowth compared to PC12 cells grown without electromagnetic stimulation. The neural stimulation patch shows great potential for wireless electromagnetic stimulation for non-invasive neurological therapeutics advancement.

人体对疾病或外伤引起的神经损伤的治愈能力有限。生物电是神经组织的典型特征，在生理和神经治疗的发展中具有至关重要的作用。在这里，创建了一个无线电磁神经刺激贴片，将通过电磁感应的刺激与通过结构各向异性的物理引导提示相结合。熔体电写生物相容性、可生物吸收的聚己内酯各向异性结构具有 80 nm 金的掠射角沉积，可直接将无线能量收集组件纳入贴片中，作为直接与神经细胞连接的电磁刺激传递系统。贴片的生物相容性以及传递电磁刺激和促进神经突生长的能力在体外得到了证实。与没有电磁刺激的 PC12 细胞相比，电磁（60 mV，40 kHz，2 小时/天，5 天）刺激的 PC12 细胞的神经突生长增加了 73.2%。神经刺激贴片显示出无线电磁刺激在非侵入性神经治疗方面的巨大潜力。