Primary cilia project from the surface of most vertebrate cells and are key in sensing extracellular signals and locally transducing this information into a cellular response. Recent findings show that primary cilia are not merely static organelles with a distinct lipid and protein composition. Instead, the function of primary cilia relies on the dynamic composition of molecules within the cilium, the context-dependent sensing and processing of extracellular stimuli, and cycles of assembly and disassembly in a cell- and tissue-specific manner. Thereby, primary cilia dynamically integrate different cellular inputs and control cell fate and function during tissue development. Here, we review the recently emerging concept of primary cilia dynamics in tissue development, organization, remodeling, and function.

中文翻译：

---

初级纤毛动力学控制组织组织和功能的新原理

初级纤毛从大多数脊椎动物细胞的表面伸出，是感知细胞外信号并将该信息局部转化为细胞反应的关键。最近的研究结果表明，初级纤毛不仅仅是具有独特脂质和蛋白质组成的静态细胞器。相反，初级纤毛的功能依赖于纤毛内分子的动态组成、细胞外刺激的环境依赖性感知和处理，以及以细胞和组织特异性方式组装和分解的循环。因此，初级纤毛动态整合不同的细胞输入并在组织发育过程中控制细胞的命运和功能。在这里，我们回顾了最近出现的组织发育、组织、重塑和功能中初级纤毛动力学的概念。