Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response to changes in physiological and environmental conditions. Here, we describe recent advances in our understanding of how functionally distinct tissue-resident mesenchymal stromal cell subpopulations orchestrate several aspects of physiological and pathophysiological adipose tissue remodeling, with a particular focus on the adaptations that occur in response to changes in energy surplus and environmental temperature. The study of adipose tissue remodeling provides a vehicle to understand the functional diversity of stromal cells and offers a lens through which several generalizable aspects of tissue reorganization can be readily observed.

中文翻译：

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间充质基质细胞作为脂肪组织重塑的导体

脂肪组织表现出卓越的扩张、收缩和重塑能力，以响应生理和环境条件的变化。在这里，我们描述了我们对功能不同的组织驻留间充质基质细胞亚群如何协调生理和病理生理脂肪组织重塑的几个方面的最新进展，特别关注响应能量过剩和环境温度的变化而发生的适应。脂肪组织重塑的研究提供了了解基质细胞功能多样性的工具，并提供了一个可以轻松观察组织重组的几个普遍方面的透镜。