Various stimuli, that is, mechanical stresses or inflammation, induce the release of adenosine triphosphate (ATP) by human periodontal ligament cells (HPDLCs). Extracellular adenosine triphosphate (eATP) affects HPDLCs’ functions such as immunosuppressive action and inflammatory responses. Lipopolysaccharide (LPS) is the key factor involved in periodontal inflammation. However, the possible correlation and detailed mechanism of inflammation-mediated eATP by LPS and inflammatory cascade formation in HPDLCs is unclarified. This study aims to examine the role of eATP on the HPDLCs’ responses concerning inflammatory actions after LPS treatment.

中文翻译：

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细胞外三磷酸腺苷调节牙周膜细胞的炎症反应

各种刺激，即机械应力或炎症，会诱导人牙周膜细胞（HPDLC）释放三磷酸腺苷（ATP）。细胞外三磷酸腺苷 (eATP) 影响 HPDLC 的功能，例如免疫抑制作用和炎症反应。脂多糖（LPS）是参与牙周炎症的关键因素。然而，LPS 介导的炎症 eATP 与 HPDLC 中炎症级联形成的可能相关性和详细机制尚不清楚。本研究旨在探讨 eATP 对 LPS 治疗后 HPDLC 炎症反应反应的作用。