INTRODUCTION Different types of psychotherapy are effective for treating major depressive disorder across groups yet show large within-group differences. Patient personality style is considered a potentially useful variable for treatment matching. OBJECTIVE This study is the first experimental test of the interaction between therapeutic approach and patients' dependent versus self-critical personality styles. METHODS A pragmatic stratified parallel trial was carried out with 100 adult patients diagnosed with DSM-IV-TR major depressive disorder. They were randomly assigned to short-term (16-20 sessions) cognitive behavioral therapy (CBT) or short-term psychodynamic psychotherapy (STPP). Patients were assessed at baseline, during therapy, post-therapy, and at 3- and 6-month follow-up. Primary outcome is depression severity measured by the Hamilton Rating Scale for Depression posttreatment. Primary analysis was by intention to treat. This trial is registered with the ISRCTN registry (www.isrctn.com), number ISRCTN17130982. RESULTS The intention-to-treat sample consisted of 100 participants; 40 with self-critical and 60 with dependent personality styles were randomized to either CBT (n = 50) or STPP (n = 50). We observed no interaction effect (-0.34 [-6.14, 5.46]) between therapy and personality style and found no evidence for a difference in effectiveness between the treatments in general in terms of symptom reduction and maintained benefits at 6-month follow-up. CONCLUSION We found no evidence that dependent versus self-critical personality styles moderate the relation between treatment and outcome in depression. Research using individual patient data could gain further insight into why specific therapeutic approaches work better for specific patients.

中文翻译：

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根特心理治疗研究：一项务实、分层、随机平行试验，探讨心理动力和认知行为干预对依赖和自我批评抑郁症患者的不同功效。

简介 不同类型的心理治疗对于治疗不同群体的重度抑郁症均有效，但组内差异较大。患者的性格风格被认为是治疗匹配的潜在有用变量。目的 这项研究是第一个关于治疗方法与患者的依赖型人格风格与自我批评型人格风格之间相互作用的实验测试。方法 对 100 名被诊断患有 DSM-IV-TR 重度抑郁症的成年患者进行了一项务实的分层平行试验。他们被随机分配接受短期（16-20 次）认知行为治疗（CBT）或短期心理动力学心理治疗（STPP）。在基线、治疗期间、治疗后以及 3 个月和 6 个月随访时对患者进行评估。主要结局是通过汉密尔顿抑郁量表治疗后测量的抑郁严重程度。主要分析是按意向治疗进行的。该试验已在 ISRCTN 注册中心注册（www.isrctn.com），编号 ISRCTN17130982。结果 意向治疗样本由 100 名参与者组成；40 名具有自我批评风格的人和 60 名具有依赖性人格风格的人被随机分配到 CBT (n = 50) 或 STPP (n = 50)。我们观察到治疗和人格风格之间没有交互作用（-0.34 [-6.14, 5.46]），并且没有发现证据表明治疗之间在症状减轻和 6 个月随访中维持益处方面的有效性存在差异。结论 我们没有发现任何证据表明依赖与自我批评的人格风格可以调节抑郁症治疗和结果之间的关系。使用个体患者数据的研究可以进一步深入了解为什么特定的治疗方法对特定患者效果更好。