Twenty-seven glaucoma patients (54 eyes in total) with well-controlled intraocular pressure were trained with binocular virtual reality visual software for 3 months to investigate whether virtual reality visual perceptual plastic training promotes macular retinal structure and macular function recovery in glaucoma patients. The thickness of peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer-inner plexiform layer (mGCIPL), and mean macular sensitivity (mMS) were evaluated 3 months after training. The mean value of pRNFL thickness in glaucoma patients did not change significantly (Z = 0.642, p = 0.521), nor did the mean value (t = 1.916, p = 0.061) and minimum value (Z = 1.428, p = 0.153) of mGCIPL after 3 months. However, the significant increases were found in superior temporal mGCIPL thickness (t = 2.430, p = 0.019) as well as superior mGCIPL thickness (t = 2.262, p = 0.028). Additionally, the mMS was increased (Z = 2.259, p < 0.05), with the inferior square to be a more pronounced mMS increase (Z = 2.070, p = 0.038). In conclusion, virtual reality visual perceptual plastic training can increase the thickness of retinal ganglion cells complexes in the macular area of glaucoma patients and improve the macular function of the corresponding area. Clinical Trial registration number: ChiCTR1900027909.

中文翻译：

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虚拟现实视觉感知整形训练促进青光眼患者视网膜结构和黄斑功能恢复。

选取眼压控制良好的27例青光眼患者（共54眼）进行为期3个月的双眼虚拟现实视觉软件训练，探讨虚拟现实视觉感知塑性训练是否促进青光眼患者黄斑视网膜结构和黄斑功能恢复。训练后3个月评估视乳头周围视网膜神经纤维层（pRNFL）、黄斑神经节细胞层-内丛状层（mGCIPL）和平均黄斑敏感度（mMS）的厚度。青光眼患者 pRNFL 厚度的平均值没有显着变化（Z = 0.642，p = 0.521），pRNFL 厚度的平均值（t = 1.916，p = 0.061）和最小值（Z = 1.428，p = 0.153）也没有显着变化。 3 个月后 mGCIPL。然而，上颞叶 mGCIPL 厚度（t = 2.430，p = 0.019）以及上 mGCIPL 厚度（t = 2.262，p = 0.028）显着增加。此外，mMS 增加（Z = 2.259，p < 0.05），下方形表示 mMS 增加更明显（Z = 2.070，p = 0.038）。综上所述，虚拟现实视知觉整形训练可以增加青光眼患者黄斑区视网膜神经节细胞复合体的厚度，改善相应区域的黄斑功能。临床试验注册号：ChiCTR1900027909。