INTRODUCTION Liver disease is a significant public health problem in the United States, with notable racial disparities in mortality. This study examines liver disease mortality trends among Black and White populations during 1999-2020. METHODS We used CDC WONDER database to ascertain liver disease age-standardized mortality rates in Black and White Americans. Annual percent change was calculated. Age-standardized absolute rate difference and rate ratios were computed by subtracting and dividing the White population's rate from that of the Black population. RESULTS Liver diseases accounted for 171,627 Black and 1,314,903 White deaths during 1999-2020. Age-standardized mortality rates for Blacks decreased from 22.5 to 20.1 per 100,000 person-years (annual percentage change -0.4%, -0.6% to -0.2%), whereas an increase was observed for Whites, from 17.9 to 25.3 per 100,000 person-years (annual percentage change 1.4%, 1.4% to 1.7%). The rate ratio decreased from 1.26 (1.22-1.29) in 1999 to 0.79 (0.78-0.81) in 2020. This pattern was evident in all census regions, more pronounced among the younger (age 25-64 years) than older (age 65+ years) population and observed across different urbanization levels. The pattern may be attributable to increasing alcohol-related liver disease and metabolic dysfunction-associated steatotic liver disease-related deaths in Whites and tapering in viral hepatitis and primary liver cancer-related deaths in Blacks. Despite notable improvement, racial disparities persist in primary liver cancer and viral hepatitis among the Black population. DISCUSSION The rise in alcohol-related liver disease and metabolic dysfunction-associated steatotic liver disease-related deaths among Whites, and enduring liver cancer and viral hepatitis disparities in the Black population, underscores the urgent need for tailored public health interventions.

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1999-2020 年美国黑人和白人肝病死亡率趋势的种族差异：CDC WONDER 数据库分析。

简介 肝病是美国的一个重大公共卫生问题，死亡率存在显着的种族差异。本研究调查了 1999 年至 2020 年期间黑人和白人的肝病死亡率趋势。方法 我们使用 CDC WONDER 数据库来确定美国黑人和白人的肝病年龄标准化死亡率。计算年度百分比变化。通过用黑人人口的比率减去并除以白人人口的比率来计算年龄标准化的绝对比率差异和比率。结果 1999 年至 2020 年间，肝脏疾病导致 171,627 名黑人和 1,314,903 名白人死亡。黑人的年龄标准化死亡率从每 10 万人年 22.5 人下降到 20.1 人（年百分比变化 -0.4%、-0.6% 到 -0.2%），而白人的年龄标准化死亡率则从每 10 万人年 17.9 人增加到 25.3 人。年（年百分比变化 1.4%、1.4% 至 1.7%）。比率从 1999 年的 1.26 (1.22-1.29) 下降到 2020 年的 0.79 (0.78-0.81)。这种模式在所有人口普查地区都很明显，年轻人（25​​-64 岁）比老年人（65 岁以上）更为明显年）人口并在不同城市化水平上观察到。这种模式可能归因于白人中酒精相关肝病和代谢功能障碍相关脂肪肝病相关死亡的增加，以及黑人中病毒性肝炎和原发性肝癌相关死亡的减少。尽管有显着改善，但黑人群体中原发性肝癌和病毒性肝炎的种族差异仍然存在。讨论白人中与酒精相关的肝病和代谢功能障碍相关的脂肪性肝病相关死亡的增加，以及黑人中持久的肝癌和病毒性肝炎的差异，强调了迫切需要量身定制的公共卫生干预措施。