Annexin A1 (ANXA1) and the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome play important roles in bone remodeling. However, expression profiles of these factors in bone cells under diabetes mellitus (DM) and estrogen-deficient conditions are poorly understood. This study investigated the immunoexpression of ANXA1 and its formyl peptide receptor 2 (FPR2), as well as NLRP3 inflammasome mediators, during remodeling of the alveolar process in diabetic and estrogen-deficient rats.

中文翻译：

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膜联蛋白 A1/FPR2 通路在雌激素缺乏雌性糖尿病大鼠牙槽骨细胞 COX2/NLRP3 炎症小体调节中的可能作用

膜联蛋白 A1 (ANXA1) 和 NOD 样受体家族含热蛋白结构域蛋白 3 (NLRP3) 炎症小体在骨重塑中发挥重要作用。然而，人们对糖尿病（DM）和雌激素缺乏条件下骨细胞中这些因子的表达谱知之甚少。本研究调查了糖尿病和雌激素缺乏大鼠肺泡过程重塑过程中 ANXA1 及其甲酰肽受体 2 (FPR2) 以及 NLRP3 炎症小体介质的免疫表达。