Mediating role of systemic inflammation in the association between heavy metals exposure and periodontitis risk,Journal of Periodontology

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Mediating role of systemic inflammation in the association between heavy metals exposure and periodontitis risk
Journal of Periodontology ( IF 4.3 ) Pub Date : 2023-11-21 , DOI: 10.1002/jper.23-0079
Mi Du _{1,

2,

3,

4} , Ke Deng ₅ , Qingqing Cai ₆ , Shixian Hu _{7,

8} , Yuntao Chen ₉ , Shulan Xu ₁₀ , Geerten-Has E Tjakkes ₁₁ , Shaohua Ge ₄ , Minghua Ge _{1,

2,

3} , An Li ₁₂

Affiliation

Otolaryngology & Head and Neck Center, Cancer Center, Department of Head and Neck Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China.
Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, China.
Clinical Research Center for Cancer of Zhejiang Province, Hangzhou, China.
School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China.
Division of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Department of Gastroenterology and Hepatology, University Medical Center Groningen (UMCG), University of Groningen, Groningen, The Netherlands.
Department of Epidemiology and Public Health, University College London, London, UK.
Center of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Department of Periodontology, Center for Dentistry and Oral Hygiene, UMCG, University of Groningen, Groningen, The Netherlands.
Department of Periodontology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.

This study evaluated the mediating role of systemic inflammation in the association between exposure to heavy metals and periodontitis in a nationwide sample of adults.

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