Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.

许多组织和器官系统具有内在的再生能力，这些能力很大程度上是由组织驻留干细胞群驱动和维持的。近年来，越来越多的证据表明细胞代谢稳态在介导干细胞命运、组织再生和稳态中发挥着核心作用。因此，对干细胞代谢稳态调节机制的透彻理解可能有助于我们了解如何维持组织稳态，并为疾病管理提供新的见解。在这篇综述中，我们总结了干细胞代谢稳态调节与分子途径之间已知的关系。我们还讨论了疾病治疗中代谢稳态的潜在靶点，并描述了这些新治疗靶点开发的当前局限性和未来方向。