BACKGROUND. Systemic administration of adeno-associated virus (AAV) can trigger life-threatening inflammatory responses, including thrombotic microangiopathy (TMA), acute kidney injury due to atypical hemolytic uremic syndrome–like complement activation, immune-mediated myocardial inflammation, and hepatic toxicity.

中文翻译：

---

全身 AAV 给药后的血栓性微血管病依赖于抗衣壳抗体

背景。腺相关病毒（AAV）的全身给药可引发危及生命的炎症反应，包括血栓性微血管病（TMA）、非典型溶血性尿毒症综合征样补体激活引起的急性肾损伤、免疫介导的心肌炎症和肝毒性。