Gamma oscillations induced by optogenetic stimulation restore functional synaptic plasticity in a mouse model of stroke, according to new research. Twelve rounds of 40 Hz stimulation were applied to the interneurons of awake mice during the acute phase after experimentally induced stroke. The stimulated mice showed significant improvements in cerebral blood flow and motor function compared with non-stimulated mice. The improvements were associated with rescue of functional plasticity and increased neuronal survival, resulting in enhanced intraregional and interregional communication.

中文翻译：

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中风后恢复突触可塑性

根据新的研究，光遗传学刺激诱导的伽马振荡可以恢复中风小鼠模型中的功能性突触可塑性。在实验诱发中风后的急性期，对清醒小鼠的中间神经元施加 12 轮 40 Hz 刺激。与未受刺激的小鼠相比，受刺激的小鼠的脑血流量和运动功能显着改善。这些改善与功能可塑性的恢复和神经元存活率的增加有关，从而增强了区域内和区域间的交流。