Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type II diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid metabolism, the potential pathogenesis and targeted therapeutic strategies.

尽管衰老传统上被视为骨关节炎 (OA) 最重要的危险因素，但越来越多的流行病学证据强调代谢异常与 OA 之间的关联，尤其是在年轻人中。肥胖和II型糖尿病等代谢异常与OA密切相关，它们同时影响负重和非负重关节，因此表明OA的发病机制比超重引起的机械应力更为复杂。本文旨在探讨代谢异常与OA风险关系的最新研究进展，包括糖脂代谢异常的影响、潜在发病机制和针对性治疗策略。