Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells lose the Y chromosome. Prevalent in haematopoietic cells, this common somatic mutation is associated with decreased longevity and an increased risk of age-related diseases, including cardiovascular disease. Haematopoietic mLOY provides further insight into the sex-specific disparities that exist in disease susceptibility.

中文翻译：

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Y染色体马赛克丢失与心血管疾病

Y 染色体马赛克丢失 (mLOY) 是指男性个体中可检测到的部分细胞丢失 ​​Y 染色体的情况。这种常见的体细胞突变在造血细胞中普遍存在，与寿命缩短和心血管疾病等与年龄相关的疾病风险增加有关。造血 mLOY 进一步深入了解疾病易感性中存在的性别特异性差异。