Use of a 3D urine-tolerant human urothelial model (3D-UHU), which recapitulates the crucial features of human urothelium, has enabled characterization and improved understanding of colonization and survival strategies used by uropathogens and commensal bacteria. The results of this study provide insights into strain-specific and species-specific infection strategies and the reciprocal host responses at the microtissue, cellular and molecular level in a human-relevant urothelial microenvironment.

中文翻译：

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人类相关尿路上皮模型提供了对感染策略和宿主反应的深入了解

使用 3D 耐尿人类尿路上皮模型 (3D-UHU) 概括了人类尿路上皮的关键特征，可以对尿路病原体和共生细菌的定植和生存策略进行表征并加深理解。这项研究的结果提供了对人类相关尿路上皮微环境中菌株特异性和物种特异性感染策略以及微组织、细胞和分子水平上宿主相互反应的见解。