Several publications from 2023 have substantiated the importance of altered NAD synthesis in kidney injury and disease progression. Now, NAD deficiency has been linked to the release of mitochondrial RNA and activation of pathways that induce inflammation. Another enzyme that governs mitochondrial function, PCK1, has also now been linked to kidney disease.

中文翻译：

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线粒体对肾脏健康和疾病影响的新证据

2023 年以来的几篇出版物证实了 NAD 合成改变在肾损伤和疾病进展中的重要性。现在，NAD 缺乏与线粒体 RNA 的释放和诱导炎症途径的激活有关。另一种控制线粒体功能的酶 PCK1 现在也与肾脏疾病有关。