Host-modulating therapy is a possible treatment for individuals that respond poorly to conventional periodontal therapy. B cells, abundant in periodontitis lesions, require the cytokines B cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) for survival and maturation. Although mRNA levels of BAFF and APRIL are increased in tissue from periodontitis lesions, it is unknown if periodontal resident cells express BAFF and/or APRIL during periodontal inflammation. In this study, we aim to analyze the expression of BAFF and APRIL in human gingival fibroblasts after stimulation with proinflammatory cytokines. Furthermore, we perform protein analysis in tissues and serum from periodontitis patients and healthy controls.

中文翻译：

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人牙龈成纤维细胞是牙周炎症期间 B 细胞激活因子的来源


对于对传统牙周治疗反应不佳的个体来说，宿主调节疗法是一种可能的治疗方法。牙周炎病变中富含 B 细胞，需要细胞因子 B 细胞激活因子 (BAFF) 和增殖诱导配体 (APRIL) 才能生存和成熟。尽管牙周炎病变组织中 BAFF 和 APRIL 的 mRNA 水平增加，但牙周驻留细胞在牙周炎症期间是否表达 BAFF 和/或 APRIL 尚不清楚。在本研究中，我们旨在分析促炎细胞因子刺激后人牙龈成纤维细胞中 BAFF 和 APRIL 的表达。此外，我们对牙周炎患者和健康对照的组织和血清进行蛋白质分析。