The widespread availability of single-cell and single-nuclear genomic tools has enabled unbiased and high-dimensional assessment of tissue immunity in the kidney. The application of these technologies to human and mouse kidney samples, combined with spatial transcriptomics, has yielded unexpected insights into how resident and infiltrating immune cells maintain tissue homeostasis and drive disease.

中文翻译：

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单细胞基因组学揭示肾组织免疫

单细胞和单核基因组工具的广泛使用使得对肾脏组织免疫的公正和高维评估成为可能。这些技术在人类和小鼠肾脏样本中的应用，与空间转录组学相结合，对驻留和浸润免疫细胞如何维持组织稳态和驱动疾病产生了意想不到的见解。