Cellular encapsulation holds promise for immunosuppression-free pancreatic islet transplantation. However, long-term graft survival remains a challenge, especially at the subcutaneous site. We harnessed temporary, controlled, inflammation-induced neovascularization to create a modified subcutaneous cavity that supports long-term survival and function of a customized islet encapsulation device without immunosuppression.

中文翻译：

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无免疫抑制的皮下胰岛移植

细胞封装有望实现无免疫抑制的胰岛移植。然而，移植物的长期存活仍然是一个挑战，特别是在皮下部位。我们利用临时的、受控的、炎症诱导的新血管形成来创建改良的皮下腔，支持定制胰岛封装装置的长期存活和功能，而无需免疫抑制。