Combined therapeutic strategies hold promises in augmenting antigen release to enhance anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond that, specific nanobiotechnologies aimed at enhancing immune potency have made substantial progress. However, there have no focused reviews on it yet. Herein, we comprehensively outlined the latest cutting-edge breakthroughs in anti-tumor immunity potentiation-enabled nanobiotechnologies, e.g., those capable of capturing neoantigens or immune cells and homing to lymph nodes. Especially, we underlined the design concepts and immune enhancement rationales of these cutting-edge nanobiotechnologies with a highlight on targeting or engineering various immune cells, organs, targets, singling pathway, physiological activity or process as well as other tumor-related targets to activate or boost immune response, immune infiltration, or mitigate immunosuppressive tumor microenvironment. Finally, we provided distinctive insights into the challenges faced by these strategies and the research direction of clinical translation, and also the potential solutions were provided. We expect this review will give more inspirations to guide or aid to design emerging nanobiotechnologies objective to truthfully improving clinical immunotherapy and elevating and bringing clinical benefits to cancer-bearing patients.

联合治疗策略有望增加抗原释放以增强抗肿瘤免疫力，这引起了众多学术评论的关注。除此之外，旨在增强免疫效力的特定纳米生物技术也取得了实质性进展。但目前尚未有针对性的评论。在此，我们全面概述了抗肿瘤免疫增强纳米生物技术的最新前沿突破，例如能够捕获新抗原或免疫细胞并归巢至淋巴结的纳米生物技术。特别是，我们强调了这些尖端纳米生物技术的设计概念和免疫增强原理，重点是靶向或工程化各种免疫细胞、器官、靶点、单一途径、生理活性或过程以及其他肿瘤相关靶点以激活或增强免疫反应、免疫浸润或减轻免疫抑制肿瘤微环境。最后，我们对这些策略所面临的挑战和临床转化的研究方向提供了独特的见解，并提供了潜在的解决方案。我们希望这篇综述能够提供更多的灵感来指导或帮助设计新兴的纳米生物技术，从而真正改善临床免疫治疗，提高癌症患者的临床获益。