Elevated levels of α-synuclein in neuronally derived extracellular vesicles (L1EVs) can predict Parkinson disease (PD) risk, according to new research. Electrochemiluminescence was used to measure α-synuclein in serum L1EVs from 365 individuals deemed at risk of developing PD on the basis of prodromal symptoms or genetic factors, 71 people with genetic or sporadic forms of PD and 140 healthy control donors. The researchers found that L1EV α-synuclein levels above 17.75 pg/ml were associated with a substantially heightened risk of PD, and they suggest that measurement of L1EV α-synuclein could aid patient stratification in the future.

最新研究表明，神经源性细胞外囊泡 (L1EV) 中 α-突触核蛋白水平升高可以预测帕金森病 (PD) 风险。使用电化学发光技术测量了 365 名因前驱症状或遗传因素而被认为有患 PD 风险的个体、71 名患有遗传性或散发性 PD 的人以及 140 名健康对照供体的血清 L1EV 中的 α-突触核蛋白。研究人员发现，L1EV α-突触核蛋白水平高于 17.75 pg/ml 与 PD 风险显着升高相关，他们建议 L1EV α-突触核蛋白的测量可以帮助将来对患者进行分层。