Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder caused by a trinucleotide repeat expansion in the FMR1 gene. A study published in Annals of Neurology has provided new insights into the pathogenesis of FXTAS by demonstrating prominent astrocyte degeneration in the white matter in individuals with the condition. The authors speculate that loss of these astrocytes could adversely affect other cells in the brain that rely on them for metabolic support, and that astrocytes might represent a novel target for the treatment of FXTAS.

中文翻译：

---

FXTAS 中的白质星形胶质细胞变性

脆性 X 相关震颤/共济失调综合征 (FXTAS) 是一种迟发性神经退行性疾病，由FMR1基因中的三核苷酸重复扩增引起。发表在《神经病学年鉴》上的一项研究通过证明患有 FXTAS 的个体白质中存在显着的星形胶质细胞变性，为 FXTAS 的发病机制提供了新的见解。作者推测，这些星形胶质细胞的丢失可能会对大脑中依赖它们提供代谢支持的其他细胞产生不利影响，并且星形胶质细胞可能代表 FXTAS 治疗的新靶点。