Despite the advances in treatment options, cardiovascular disease (CVDs) remains the leading cause of death over the world. Chronic inflammatory response and irreversible fibrosis are the main underlying pathophysiological causes of progression of CVDs. In recent decades, cardiac macrophages have been recognized as main regulatory players in the development of these complex pathophysiological conditions. Numerous approaches aimed at macrophages have been devised, leading to novel prospects for therapeutic interventions. Our review covers the advancements in macrophage-centric treatment plans for various pathologic conditions and examines the potential consequences and obstacles of employing macrophage-targeted techniques in cardiac diseases.

尽管治疗方案取得了进步，心血管疾病（CVD）仍然是全世界死亡的主要原因。慢性炎症反应和不可逆纤维化是CVD进展的主要病理生理学原因。近几十年来，心脏巨噬细胞已被认为是这些复杂病理生理状况发展中的主要调节因素。人们已经设计了许多针对巨噬细胞的方法，为治疗干预带来了新的前景。我们的综述涵盖了针对各种病理状况的以巨噬细胞为中心的治疗计划的进展，并研究了在心脏病中采用巨噬细胞靶向技术的潜在后果和障碍。