Macrophages are important components of the immune system. Mature macrophages can be recruited to tumor microenvironment that affect tumor cell proliferation, invasion and metastasis, extracellular matrix remodeling, immune suppression, as well as chemotherapy resistance. Classically activated type I macrophages (M1) exhibited marked tumor killing and phagocytosis. Therefore, using macrophages for adoptive cell therapy has attracted attention and become one of the most effective strategies for cancer treatment. Through cytokines and/or chemokines, macrophage can inhibit myeloid cells recruitment, and activate anti-tumor and immune killing functions. Applying macrophages for anti-tumor delivery is one of the most promising approaches for cancer therapy. This review article introduces the role of macrophages in tumor development and drug resistance, and the possible clinical application of targeting macrophages for overcoming drug resistance and enhancing cancer therapeutics, as well as its challenges.

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肿瘤相关巨噬细胞在癌症治疗中的前景广阔

巨噬细胞是免疫系统的重要组成部分。成熟的巨噬细胞可以被招募到肿瘤微环境中，影响肿瘤细胞的增殖、侵袭和转移、细胞外基质重塑、免疫抑制以及化疗耐药。经典激活的 I 型巨噬细胞 (M1) 表现出显着的肿瘤杀伤和吞噬作用。因此，利用巨噬细胞进行过继细胞治疗引起了人们的关注，并成为癌症治疗最有效的策略之一。通过细胞因子和/或趋化因子，巨噬细胞可以抑制骨髓细胞的募集，并激活抗肿瘤和免疫杀伤功能。应用巨噬细胞进行抗肿瘤递送是最有前途的癌症治疗方法之一。本文介绍了巨噬细胞在肿瘤发生和耐药中的作用，以及靶向巨噬细胞克服耐药性和增强癌症治疗的可能的临床应用及其挑战。