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Why have T cell-inducing vaccines for HIV failed so far?
Nature Reviews Immunology ( IF 100.3 ) Pub Date : 2024-01-10 , DOI: 10.1038/s41577-024-00989-8
Alexandra Flemming

The failure of T cell-targeted vaccines for HIV in clinical trials is likely due to impaired degranulation of low-avidity CD8+ T cells in the context of low levels of antigen presentation.

中文翻译:

为什么 T 细胞诱导的 HIV 疫苗迄今为止失败了?

HIV T 细胞靶向疫苗在临床试验中的失败可能是由于低亲和力 CD8+ T 细胞在抗原呈递水平较低的情况下脱颗粒受损所致。
更新日期:2024-01-10
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