Extensive neuroimaging research on brain structural and functional correlates of suicide has produced inconsistent results. Despite increasing recognition that damage in multiple different brain locations that causes the same symptom can map to a common brain network, there is still a paucity of research investigating network localization of suicide. To clarify this issue, we initially identified brain structural and functional damage locations in relation to suicide from 63 published studies with 2135 suicidal and 2606 nonsuicidal individuals. By applying novel functional connectivity network mapping to large-scale discovery and validation resting-state functional magnetic resonance imaging datasets, we mapped these affected brain locations to 3 suicide brain damage networks corresponding to different imaging modalities. The suicide gray matter volume damage network comprised widely distributed brain areas primarily involving the dorsal default mode, basal ganglia, and anterior salience networks. The suicide task-induced activation damage network was similar to but less extensive than the gray matter volume damage network, predominantly implicating the same canonical networks. The suicide resting-state activity damage network manifested as a localized set of brain regions encompassing the orbitofrontal cortex and middle cingulate cortex. Our findings not only may help reconcile prior heterogeneous neuroimaging results, but also may provide insights into the neurobiological mechanisms of suicide from a network perspective, which may ultimately inform more targeted and effective strategies to prevent suicide.

中文翻译：

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自杀的脑结构和功能损伤网络定位

关于自杀的大脑结构和功能相关性的广泛神经影像学研究产生了不一致的结果。尽管人们越来越认识到导致相同症状的多个不同大脑位置的损伤可以映射到一个共同的大脑网络，但仍然缺乏调查自杀网络定位的研究。为了澄清这个问题，我们最初从 63 项已发表的研究中确定了与自杀相关的大脑结构和功能损伤部位，研究对象包括 2135 名自杀者和 2606 名非自杀者。通过将新颖的功能连接网络映射应用于大规模发现和验证静息态功能磁共振成像数据集，我们将这些受影响的大脑位置映射到与不同成像方式相对应的 3 个自杀性脑损伤网络。自杀性灰质体积损伤网络由广泛分布的大脑区域组成，主要涉及背侧默认模式、基底神经节和前突网络。自杀任务诱发的激活损伤网络与灰质体积损伤网络相似，但范围较小，主要涉及相同的规范网络。自杀静息态活动损伤网络表现为一组局部大脑区域，包括眶额皮层和中扣带皮层。我们的研究结果不仅可能有助于协调先前的异质神经影像结果，而且还可能从网络角度提供对自杀的神经生物学机制的见解，这可能最终为预防自杀提供更有针对性和更有效的策略。