Here, I introduce the concept of ‘integrated organ immunity’ to explain how the innate and adaptive immune systems and non-haematopoietic cells can interact in tissues to generate enduring protective immunity against diverse pathogens in an antigen-agnostic manner. Considering immune responses through this framework could enable the design of a new class of vaccines termed ‘universal vaccines’ that are not pathogen specific. Considering immune responses through the framework of ‘integrated organ immunity’ could enable the design of a new class of universal vaccines.

中文翻译：

---

综合器官免疫：通用疫苗的途径

在这里，我引入“整合器官免疫”的概念，解释先天性和适应性免疫系统以及非造血细胞如何在组织中相互作用，以与抗原无关的方式产生针对多种病原体的持久保护性免疫。通过这个框架考虑免疫反应可以设计出一种新型疫苗，称为“通用疫苗”，这种疫苗不是针对病原体的。通过“综合器官免疫”框架考虑免疫反应可以设计出一类新型通用疫苗。