Over the last 30 years, knowledge of the epidemiology of osteoarthritis (OA) has dramatically advanced, and has been on the forefront of disseminating research findings from large OA cohort studies, including the Johnston County OA Project (JoCoOA). The JoCoOA is a population-based, prospective longitudinal cohort that began roughly 30 years ago with a key focus on understanding prevalence, incidence, and progression of OA, as well as its risk factors, in a predominantly rural population of Black and White adults 45+ years old in a county in the southeastern United States. Selected OA results that will be discussed in this review include racial differences, lifetime risk, biomarkers, mortality, and OA risk factors. The new Johnston County Health Study will also be introduced. This new cohort study of OA and comorbid conditions builds upon current OA knowledge and JoCoOA infrastructure and is designed to reflect changes in demographics and urbanization in the county and the region.

中文翻译：

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回顾约翰斯顿县骨关节炎项目 30 多年，同时展望约翰斯顿县健康研究：叙述性回顾

在过去的 30 年里，人们对骨关节炎 (OA) 流行病学的了解取得了巨大进步，并且一直处于传播大型 OA 队列研究（包括约翰斯顿县 OA 项目 (JoCoOA)）的研究成果的最前沿。 JoCoOA 是一个基于人群的前瞻性纵向队列，大约开始于 30 年前，重点关注以农村黑人和白人成年人为主的人口中了解 OA 的患病率、发病率和进展及其危险因素 45 + 岁，居住在美国东南部的一个县。本综述将讨论的选定 OA 结果包括种族差异、终生风险、生物标志物、死亡率和 OA 风险因素。新的约翰斯顿县健康研究也将推出。这项关于 OA 和合并症的新队列研究建立在当前 OA 知识和 JoCoOA 基础设施的基础上，旨在反映该县和该地区人口统计和城市化的变化。