Several novel personalized therapies focus on targeting neoantigens. Such strategies require the identification of suitable vaccine neoepitopes or neoantigen-specific T cell receptor (TCR) clonotypes. Herein, we discuss a recently published report that describes a combined transcriptional and phenotype signature, NeoTCRPBL, that enables the minimally invasive identification of rare neoantigen-specific TCRs from peripheral blood that might enable more-effective T cell-based therapies against cancer.

中文翻译：

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利用新抗原特异性 T 细胞进行精准癌症免疫治疗

几种新颖的个性化疗法专注于针对新抗原。此类策略需要鉴定合适的疫苗新表位或新抗原特异性 T 细胞受体 (TCR) 克隆型。在此，我们讨论最近发表的一份报告，该报告描述了组合转录和表型特征 NeoTCRPBL，该报告能够从外周血中微创鉴定罕见的新抗原特异性 TCR，从而可能实现更有效的基于 T 细胞的癌症疗法。