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Hypercholesterolemia diagnosis by a biosensor based on photonic crystal PANDA structure
Optical Review ( IF 1.2 ) Pub Date : 2024-01-22 , DOI: 10.1007/s10043-023-00859-z
Esmat Rafiee , Elham Rafiei

A biosensor based on 2-D photonic crystals is presented and considered. The proposed structure is made of 24 × 23 Si rods in the air background. The presented biosensor would be considered for detection of Cholesterol concentrations in blood samples, which can aid physicians in diagnosis of Hypercholesterolemia and heart diseases in early stages. To facilitate the designation and fabrication processes and overcome the gain and nonlinearity problems, only linear rods would be utilized. The presented structure operates based on the interference and scattering effects of Si defect rods positioned in the structure (black rods operate as the confining sensing media and dark green rods function as the coupling rods). The PANDA (the proposed structure indicates a PANDA face)-shaped waveguides can filter the resonant wavelengths. For studying the functionality of the proposed biosensor, photonic band gap (by the plane wave expansion (PWE) method) and field distribution (by the finite-difference-time-domain (FDTD) method) spectra should be considered. The appropriate dimension of the proposed biosensor (111.78 μm2) makes it a considerable option for utilization in bio-optical integrated circuits. Finally, for the Cholesterol concentrations in blood samples, the remarkable sensitivity (595.74 nm/RIU “RIU stands for refractive index unit”), quality factor (35–46), detection limit (6.1e−3–6.7e−3) RIU and figure of merit (14.89–16.3) RIU−1 were achieved.



中文翻译:

基于光子晶体PANDA结构的生物传感器诊断高胆固醇血症

提出并考虑了一种基于二维光子晶体的生物传感器。所提出的结构由空气背景中的 24 × 23 硅棒组成。所提出的生物传感器将被考虑用于检测血液样本中的胆固醇浓度,这可以帮助医生早期诊断高胆固醇血症和心脏病。为了促进设计和制造过程并克服增益和非线性问题,将仅使用线性杆。所提出的结构基于位于结构中的硅缺陷棒的干涉和散射效应来工作(黑色棒作为限制传感介质,深绿色棒作为耦合棒)。 PANDA(所提出的结构表示PANDA面)形状的波导可以过滤谐振波长。为了研究所提出的生物传感器的功能,应考虑光子带隙(通过平面波展开(PWE)方法)和场分布(通过时域有限差分(FDTD)方法)光谱。所提出的生物传感器的适当尺寸(111.78 μm 2)使其成为生物光学集成电路中使用的重要选择。最后,对于血液样本中的胆固醇浓度,显着的灵敏度(595.74 nm/RIU“RIU 代表折射率单位”)、品质因数 (35–46)、检测限 (6.1e−3–6.7e−3) RIU达到了品质因数 (14.89–16.3) RIU −1 。

更新日期:2024-01-22
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