Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial,Arthritis & Rheumatology

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Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2024-01-25 , DOI: 10.1002/art.42811
Karen H. Costenbader _{1,

2} , Nancy R. Cook _{2,

3,

4} , I‐Min Lee _{2,

3,

4} , Jill Hahn ₃ , Joseph Walter ₄ , Vadim Bubes ₄ , Gregory Kotler ₄ , Nicole Yang _{1,

2} , Sonia Friedman _{2,

5} , Erik K. Alexander _{2,

6} , JoAnn E. Manson _{2,

3,

4}

Affiliation

In the 5.3-year randomized, 2 × 2 factorial, double-blind, placebo-controlled Vitamin D and Omega-3 Trial (VITAL), vitamin D supplementation reduced autoimmune disease (AD) incidence (hazard ratio [HR] 0.78, 95% confidence interval [CI] 0.61–0.99). Omega-3 (n-3) fatty acid supplementation showed a statistically nonsignificant reduction (HR 0.85, 95% CI 0.67–1.08). We aimed to confirm further AD cases arising during and after randomization and assess sustained effects with two years of postintervention observation.

中文翻译：

维生素 D 和海洋 n-3 脂肪酸预防自身免疫性疾病：双盲、安慰剂对照试验完成两年后的结果

在为期 5.3 年的随机、2 × 2 析因、双盲、安慰剂对照维生素 D 和 Omega-3 试验 (VITAL) 中，维生素 D 补充剂可降低自身免疫性疾病 (AD) 发病率（风险比 [HR] 0.78，95%）置信区间 [CI] 0.61–0.99）。补充 Omega-3 (n-3) 脂肪酸显示出统计上无显着性降低（HR 0.85，95% CI 0.67–1.08）。我们的目的是确认随机化期间和之后出现的更多 AD 病例，并通过两年的干预后观察评估持续效果。

更新日期：2024-01-25

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