Dry-eye disease (DED) is a chronic progressive ocular surface disorder with limited studies in the pediatric population. The Academy of Ophthalmology's IRIS® Registry was leveraged to investigate the prevalence of DED in the pediatric population (PDED, patients <18 years old) and the demographic differences of DED between pediatric and adult patients (ADED). Retrospective cohort study. Patients with DED between January 1st, 2013 and December 31st, 2019 (N = 4,795,979) were included. Descriptive statistics, Pearson's chi-squared tests and two-sample proportions tests were conducted to compare key demographic distributions between the ADED and PDED cohorts. The average age at onset for ADED patients was 61.06 (±14.75) years and for PDED patients was 12.51 (±3.86). The overall tests for independence and the individual tests of proportions of each category were statistically significant for all demographic characteristics (p < 0.001). Characteristics with the largest discrepancies between patients of PDED and the IRIS Registry pediatric patient pool (PIRIS) included female sex (58.08 % vs. 50.60 %), male sex (41.58 % vs. 48.78 %) and Asian race (6.02 % vs. 3.11 %) respectively. Within the PDED cohort, females were at higher risk of PDED (58 % vs. 42 %). PDED was more prevalent in children with refractive errors (76 %) and eyelid/conjunctival disorders (41 %). Characteristics with the largest discrepancies between PDED and ADED patients included female sex (58.08 % vs. 68.12 %), male sex (41.58 % vs. 31.55 %) and Caucasian race (50.24 % vs. 67.06 %) respectively. Significant differences in the PDED cohort are demonstrated in this study. PDED was more prevalent in the female sex and Caucasian race compared to PIRIS and was more commonly associated with refractive errors and eyelid/conjunctival disorders.

中文翻译：

---

美国儿童干眼病的流行病学：IRIS® 注册（智能视觉研究）分析

干眼病（DED）是一种慢性进行性眼表疾病，在儿科人群中的研究有限。利用眼科学会的 IRIS® 登记系统来调查儿科人群中 DED 的患病率（PDED，年龄<18 岁的患者）以及儿科和成人患者 (ADED) 之间 DED 的人口统计学差异。回顾性队列研究。纳入2013年1月1日至2019年12月31日期间患有DED的患者（N = 4,795,979）。进行描述性统计、皮尔逊卡方检验和双样本比例检验来比较 ADED 和 PDED 队列之间的关键人口统计分布。 ADED 患者的平均发病年龄为 61.06 (±14.75) 岁，PDED 患者的平均发病年龄为 12.51 (±3.86) 岁。对于所有人口统计特征，独立性的总体测试和每个类别比例的单独测试均具有统计显着性（p < 0.001）。 PDED 患者与 IRIS 注册儿科患者库 (PIRIS) 之间差异最大的特征包括女性（58.08 % vs. 50.60 %）、男性（41.58 % vs. 48.78 %）和亚洲人种（6.02 % vs. 3.11） ％） 分别。在 PDED 队列中，女性患 PDED 的风险较高（58% vs. 42%）。 PDED 在患有屈光不正 (76%) 和眼睑/结膜疾病 (41%) 的儿童中更为常见。 PDED和ADED患者之间差异最大的特征分别包括女性（58.08% vs. 68.12%）、男性（41.58% vs. 31.55%）和白人种族（50.24% vs. 67.06%）。本研究证明了 PDED 队列中的显着差异。与 PIRIS 相比，PDED 在女性和白种人种中更为普遍，并且更常与屈光不正和眼睑/结膜疾病相关。