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Ketogenesis favors oxidative phosphorylation to promote disease tolerance
Trends in Endocrinology & Metabolism ( IF 10.9 ) Pub Date : 2024-01-31 , DOI: 10.1016/j.tem.2024.01.006
Kátia Jesus , Luís F. Moita

is an opportunistic pathogen of great medical relevance, although the mechanisms involved in chronic infection are unclear. have now shown that systemic and local pathogen-induced ketone bodies (KBs) select strains that preserve respiratory integrity by failing to substantially increase glycolysis, which drives immunopathology resulting from resistance mechanisms.

中文翻译:

生酮有利于氧化磷酸化以促进疾病耐受性

尽管慢性感染的机制尚不清楚,但它是一种具有重大医学意义的机会性病原体。现在已经表明,全身和局部病原体诱导的酮体(KB)选择通过未能大幅增加糖酵解来保持呼吸完整性的菌株,糖酵解驱动由耐药机制引起的免疫病理学。
更新日期:2024-01-31
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