Erosive hand osteoarthritis (eHOA) is a subtype of hand osteoarthritis (OA) that develops in finger joints with pre-existing OA and is differentiated by clinical characteristics (hand pain/disability, inflammation, and erosions) that suggest inflammatory or metabolic processes. This was a longitudinal nested case-cohort design among Osteoarthritis Initiative participants who had hand radiographs at baseline and 48-months, and biospecimens collected at baseline. We classified incident radiographic eHOA in individuals with ≥1 joint with Kellgren-Lawrence ≥2 and a central erosion present at 48-months but not at baseline. We used a random representative sample (n = 1282) for comparison. We measured serum biomarkers of inflammation, insulin resistance and dysglycemia, and adipokines using immunoassays and enzymatic colorimetric procedures, blinded to case status. Eighty-six participants developed incident radiographic eHOA. In the multivariate analyses adjusted for age, gender, race, smoking, and body mass index, and after adjustment for multiple analyses, incident radiographic eHOA was associated with elevated levels of interleukin-7 (risk ratio (RR) per SD = 1.30 [95% confidence interval (CI) 1.09, 1.55] p trend 0.01). This exploratory study suggests an association of elevated interleukin-7, an inflammatory cytokine, with incident eHOA, while other cytokines or biomarkers of metabolic inflammation were not associated. Interleukin-7 may mediate inflammation and tissue damage in susceptible osteoarthritic finger joints and participate in erosive progression.

中文翻译：

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骨关节炎倡议队列中炎症和代谢生物标志物与手部糜烂性骨关节炎的关联

糜烂性手部骨关节炎 (eHOA) 是手部骨关节炎 (OA) 的一种亚型，在已有 OA 的手指关节中发生，并根据表明炎症或代谢过程的临床特征（手部疼痛/残疾、炎症和糜烂）进行区分。这是骨关节炎倡议参与者的纵向嵌套病例队列设计，他们在基线和 48 个月时进行了手部 X 光检查，并在基线时收集了生物样本。我们将放射照相 eHOA 分类为具有 ≥1 个关节、Kellgren-Lawrence ≥2 个关节且 48 个月时出现中心侵蚀但基线时未出现的个体。我们使用随机代表性样本（n = 1282）进行比较。我们使用免疫测定和酶比色程序测量了炎症、胰岛素抵抗和血糖异常以及脂肪因子的血清生物标志物，对病例状态不知情。 86 名参与者制定了事件射线照相 eHOA。在根据年龄、性别、种族、吸烟和体重指数进行调整的多变量分析中，以及在对多项分析进行调整后，放射照相 eHOA 事件与白细胞介素 7 水平升高相关（每 SD 的风险比 (RR) = 1.30 [95] % 置信区间 (CI) 1.09, 1.55] p 趋势 0.01)。这项探索性研究表明，白细胞介素 7（一种炎症细胞因子）升高与 eHOA 事件相关，而代谢炎症的其他细胞因子或生物标志物则没有相关性。 Interleukin-7 可能介导易受影响的骨关节炎手指关节的炎症和组织损伤，并参与侵蚀进展。