The Rotterdam Study is a population-based cohort study, started in 1990 in the district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the prevalence and incidence, unravel the etiology, and identify targets for prediction, prevention or intervention of multifactorial diseases in mid-life and elderly. The study currently includes 17,931 participants (overall response rate 65%), aged 40 years and over, who are examined in-person every 3 to 5 years in a dedicated research facility, and who are followed-up continuously through automated linkage with health care providers, both regionally and nationally. Research within the Rotterdam Study is carried out along two axes. First, research lines are oriented around diseases and clinical conditions, which are reflective of medical specializations. Second, cross-cutting research lines transverse these clinical demarcations allowing for inter- and multidisciplinary research. These research lines generally reflect subdomains within epidemiology. This paper describes recent methodological updates and main findings from each of these research lines. Also, future perspective for coming years highlighted.

鹿特丹研究是一项以人群为基础的队列研究，于 1990 年在荷兰鹿特丹市奥莫德区启动，旨在描述患病率和发病率，阐明病因，并确定预测、预防或治疗的目标。中老年人多因素疾病的干预。该研究目前包括 17,931 名年龄在 40 岁及以上的参与者（总体回应率为 65%），他们每 3 至 5 年在专门的研究机构进行一次现场检查，并通过与医疗保健的自动联系进行持续随访区域和国家的供应商。鹿特丹研究的研究沿着两个轴进行。首先，研究方向围绕疾病和临床状况，这反映了医学专业。其次，交叉研究线跨越这些临床界限，允许跨学科和多学科研究。这些研究方向通常反映流行病学的子领域。本文描述了每个研究方向的最新方法更新和主要发现。此外，还强调了未来几年的前景。