Bed-rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism,Journal of Cachexia, Sarcopenia and Muscle

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Bed-rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism
Journal of Cachexia, Sarcopenia and Muscle ( IF 8.9 ) Pub Date : 2024-02-12 , DOI: 10.1002/jcsm.13431
Natalie F. Shur _{1,

2} , Elizabeth J. Simpson _{2,

3} , Hannah Crossland _{2,

3} , Despina Constantin _{2,

3} , Sally M. Cordon ₃ , Dumitru Constantin‐Teodosiu ₃ , Francis B. Stephens ₄ , Matthew S. Brook _{2,

3} , Philip J. Atherton _{2,

3} , Kenneth Smith _{2,

3} , Daniel J. Wilkinson _{2,

3} , Olivier E. Mougin _{2,

5} , Christopher Bradley _{2,

5} , Ian A. Macdonald _{2,

3} , Paul L. Greenhaff _{1,

2,

3}

Affiliation

Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same individuals. Moreover, the impact of short-term exercise-supplemented remobilization (ESR) on muscle volume, protein turnover and leg glucose uptake (LGU) in humans is unknown.

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