Interleukin-23 (IL-23) is a crucial cytokine implicated in chronic inflammation and autoimmunity, associated with various diseases such as psoriasis, psoriatic arthritis, and systemic lupus erythematosus (SLE). This study aimed to create and characterize a transgenic mouse model overexpressing human IL-23A (TghIL-23A), providing a valuable tool for investigating the pathogenic role of human IL-23A and evaluating the efficacy of anti–human IL-23A therapeutics.

中文翻译：

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新型人白细胞介素23A过表达系统性红斑狼疮小鼠模型

白介素 23 (IL-23) 是一种与慢性炎症和自身免疫相关的重要细胞因子，与牛皮癣、牛皮癣关节炎和系统性红斑狼疮 (SLE) 等多种疾病相关。本研究旨在创建并表征过表达人 IL-23A (TghIL-23A) 的转基因小鼠模型，为研究人 IL-23A 的致病作用和评估抗人 IL-23A 疗法的功效提供有价值的工具。