Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing: A Prespecified Secondary Analysis of a Two-Year, Multicenter, Double-Blind, Placebo-Controlled Clinical Trial,Arthritis & Rheumatology

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Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing: A Prespecified Secondary Analysis of a Two-Year, Multicenter, Double-Blind, Placebo-Controlled Clinical Trial
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2024-02-18 , DOI: 10.1002/art.42831
Guoqi Cai _{1,

2} , Laura L. Laslett ₂ , Michael Thompson _{2,

3} , Flavia Cicuttini ₄ , Catherine Hill ₅ , Anita E. Wluka ₄ , Lyn March ₆ , Yuanyuan Wang ₄ , Petr Otahal ₂ , James D. Stoney _{7,

8} , Benny Antony ₂ , Kathy Buttigieg ₂ , Tania Winzenberg ₂ , Graeme Jones ₂ , Dawn Aitken ₂

Affiliation

To determine the effect of zoledronic acid (ZA) on the risk of total knee replacement (TKR) in patients with symptomatic knee osteoarthritis and without severe joint space narrowing (JSN).

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