Static ice storage has long been the standard-of-care for lung preservation, although freezing injury limits ischemic time (IT). Controlled hypothermic storage (CHS) at elevated temperature could safely extend IT. This retrospective analysis assesses feasibility and safety of CHS with IT>15h. Three lung transplant (LuTx) centers (April-October 2023) included demographics, storage details, IT and short-term outcome from 13 LuTx recipients (8 male, 59 years old). Donor lungs were preserved in a portable CHS-device at 7(5-9.3)°C. Indication was overnight bridging and/or long-distance transport. IT of second-implanted lung was 17.3(15.1-22)h. LuTx were successful, 4/13 exhibited primary graft dysfunction grade 3 within 72h and 0/13 at 72h. Post-LuTx mechanical ventilation was 29(7-442)h. Intensive care unit stay was 9(5-28) and hospital stay 30(16-90) days. Four patients needed post-operative extracorporeal membrane oxygenation (ECMO). One patient died (day seven) following malpositioning of an ECMO cannula. This multi-center experience demonstrates the possibility of safely extending IT>15h by CHS.

中文翻译：

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在肺移植中使用受控低温储存延长缺血时间（> 15 小时）：多中心经验

尽管冷冻损伤限制了缺血时间（IT），但静态冰储存长期以来一直是肺保存的护理标准。高温下的受控低温储存 (CHS) 可以安全地延长 IT 时间。该回顾性分析评估了 IT>15 小时的 CHS 的可行性和安全性。三个肺移植 (LuTx) 中心（2023 年 4 月至 10 月）包括 13 名 LuTx 接受者（8 名男性，59 岁）的人口统计数据、存储详细信息、IT 和短期结果。供体肺保存在便携式 CHS 装置中，温度为 7(5-9.3)°C。适应症是过夜桥接和/或长途运输。第二次植入肺的IT为17.3(15.1-22)h。LuTx 是成功的，4/13 的患者在 72 小时内表现出 3 级原发性移植物功能障碍，0/13 的患者在 72 小时内表现出 3 级原发性移植物功能障碍。LuTx 后机械通气时间为 29（7-442）小时。重症监护室住院时间为 9（5-28）天，住院时间为 30（16-90）天。四名患者术后需要体外膜肺氧合（ECMO）。一名患者因 ECMO 插管错位而死亡（第七天）。这种多中心经验证明了通过 CHS 安全延长 IT>15 小时的可能性。